diff --git a/src/cache/DbQueryResultCache.ts b/src/cache/DbQueryResultCache.ts
index 14513e02a9..2b55163268 100644
--- a/src/cache/DbQueryResultCache.ts
+++ b/src/cache/DbQueryResultCache.ts
@@ -158,7 +158,11 @@ export class DbQueryResultCache implements QueryResultCache {
      * Stores given query result in the cache.
      */
     async storeInCache(options: QueryResultCacheOptions, savedCache: QueryResultCacheOptions|undefined, queryRunner?: QueryRunner): Promise<void> {
-        queryRunner = this.getQueryRunner(queryRunner);
+        const shouldCreateQueryRunner = queryRunner === undefined || queryRunner?.getReplicationMode() === "slave";
+
+        if (queryRunner === undefined || shouldCreateQueryRunner) {
+            queryRunner = this.connection.createQueryRunner("master");
+        }
 
         let insertedValues: ObjectLiteral = options;
         if (this.connection.driver instanceof SqlServerDriver) { // todo: bad abstraction, re-implement this part, probably better if we create an entity metadata for cache table
@@ -203,6 +207,10 @@ export class DbQueryResultCache implements QueryResultCache {
                 .values(insertedValues)
                 .execute();
         }
+
+        if (shouldCreateQueryRunner) {
+            await queryRunner.release();
+        }
     }
 
     /**
diff --git a/src/driver/mongodb/MongoQueryRunner.ts b/src/driver/mongodb/MongoQueryRunner.ts
index 6f3dab66f3..45ce50dbeb 100644
--- a/src/driver/mongodb/MongoQueryRunner.ts
+++ b/src/driver/mongodb/MongoQueryRunner.ts
@@ -46,8 +46,9 @@ import {TableUnique} from "../../schema-builder/table/TableUnique";
 import {Broadcaster} from "../../subscriber/Broadcaster";
 import {TableCheck} from "../../schema-builder/table/TableCheck";
 import {TableExclusion} from "../../schema-builder/table/TableExclusion";
-import { TypeORMError } from "../../error";
-
+import {TypeORMError} from "../../error";
+import {ReplicationMode} from "../types/ReplicationMode";
+ 
 /**
  * Runs queries on a single MongoDB connection.
  */
@@ -507,6 +508,10 @@ export class MongoQueryRunner implements QueryRunner {
         throw new TypeORMError(`Schema update queries are not supported by MongoDB driver.`);
     }
 
+    getReplicationMode(): ReplicationMode {
+        return 'master';
+    }
+
     /**
      * Checks if database with the given name exist.
      */
diff --git a/src/query-runner/BaseQueryRunner.ts b/src/query-runner/BaseQueryRunner.ts
index 37fb0f0702..8e15bee4a2 100644
--- a/src/query-runner/BaseQueryRunner.ts
+++ b/src/query-runner/BaseQueryRunner.ts
@@ -203,6 +203,10 @@ export abstract class BaseQueryRunner {
         }
     }
 
+    getReplicationMode(): ReplicationMode {
+        return this.mode;
+    }
+
     // -------------------------------------------------------------------------
     // Protected Methods
     // -------------------------------------------------------------------------
diff --git a/src/query-runner/QueryRunner.ts b/src/query-runner/QueryRunner.ts
index e24dcfd8e8..4d07569b32 100644
--- a/src/query-runner/QueryRunner.ts
+++ b/src/query-runner/QueryRunner.ts
@@ -14,6 +14,7 @@ import {TableCheck} from "../schema-builder/table/TableCheck";
 import {IsolationLevel} from "../driver/types/IsolationLevel";
 import {TableExclusion} from "../schema-builder/table/TableExclusion";
 import {QueryResult} from "./QueryResult";
+import {ReplicationMode} from "../driver/types/ReplicationMode";
 
 /**
  * Runs queries on a single database connection.
@@ -149,6 +150,11 @@ export interface QueryRunner {
      */
     getViews(viewPaths?: string[]): Promise<View[]>;
 
+    /**
+     * Returns replication mode (ex: `master` or `slave`).
+     */
+    getReplicationMode(): ReplicationMode;
+
     /**
      * Checks if a database with the given name exist.
      */
diff --git a/test/github-issues/5919/entities.ts b/test/github-issues/5919/entities.ts
new file mode 100644
index 0000000000..9c02b767e0
--- /dev/null
+++ b/test/github-issues/5919/entities.ts
@@ -0,0 +1,10 @@
+import { Column, Entity, PrimaryGeneratedColumn } from "../../../src";
+
+@Entity()
+export class Comment {
+    @PrimaryGeneratedColumn()
+    id: number;
+
+    @Column()
+    text: string;
+}
diff --git a/test/github-issues/5919/issue-6399.ts b/test/github-issues/5919/issue-6399.ts
new file mode 100644
index 0000000000..96ca851733
--- /dev/null
+++ b/test/github-issues/5919/issue-6399.ts
@@ -0,0 +1,107 @@
+import { expect } from "chai";
+import Sinon from "sinon";
+import { Connection } from "../../../src";
+import {
+    closeTestingConnections,
+    createTestingConnections,
+    reloadTestingDatabases,
+} from "../../utils/test-utils";
+import { Comment } from "./entities";
+
+describe("github issues > #5919 Caching won't work with replication enabled", () => {
+    let connections: Connection[];
+
+    beforeEach(async () => {
+        connections = await createTestingConnections({
+            entities: [Comment],
+            schemaCreate: true,
+            dropSchema: true,
+            cache: true,
+            enabledDrivers: ["postgres"],
+        });
+        await reloadTestingDatabases(connections);
+    });
+    afterEach(() => closeTestingConnections(connections));
+
+    it("should not another queryRunner for cache with a given masterQueryRunner", () =>
+        Promise.all(
+            connections.map(async (connection) => {
+                const comment1 = new Comment();
+                comment1.text = "tata";
+                await connection.manager.save(comment1);
+
+                const masterQueryRunner = connection.createQueryRunner(
+                    "master"
+                );
+                const createQueryRunnerSpy = Sinon.spy(
+                    connection,
+                    "createQueryRunner"
+                );
+
+                const results1 = await connection
+                    .createQueryBuilder()
+                    .from(Comment, "c")
+                    .cache(true)
+                    .setQueryRunner(masterQueryRunner)
+                    .getRawMany();
+
+                expect(results1.length).eq(1);
+
+                expect(createQueryRunnerSpy.notCalled);
+
+                // add another one and ensure cache works
+                const comment2 = new Comment();
+                comment2.text = "tata";
+                await connection.manager.save(comment2);
+
+                const results2 = await connection
+                    .createQueryBuilder()
+                    .from(Comment, "c")
+                    .cache(true)
+                    .setQueryRunner(masterQueryRunner)
+                    .getRawMany();
+
+                expect(results2.length).eq(1);
+            })
+        ));
+
+    it("should create another queryRunner for cache with a given slaveQueryRunner", () =>
+        Promise.all(
+            connections.map(async (connection) => {
+                const comment1 = new Comment();
+                comment1.text = "tata";
+                await connection.manager.save(comment1);
+
+                const slaveQueryRunner = connection.createQueryRunner("slave");
+                const createQueryRunnerSpy = Sinon.spy(
+                    connection,
+                    "createQueryRunner"
+                );
+
+                const results1 = await connection
+                    .createQueryBuilder()
+                    .from(Comment, "c")
+                    .cache(true)
+                    .setQueryRunner(slaveQueryRunner)
+                    .getRawMany();
+
+                expect(results1.length).eq(1);
+
+                expect(createQueryRunnerSpy.calledOnce);
+
+                // add another one and ensure cache works
+                const comment2 = new Comment();
+                comment2.text = "tata";
+                await connection.manager.save(comment2);
+
+                const results2 = await connection
+                    .createQueryBuilder()
+                    .from(Comment, "c")
+                    .cache(true)
+                    .setQueryRunner(slaveQueryRunner)
+                    .getRawMany();
+
+                expect(results2.length).eq(1);
+            })
+        ));
+});