diff --git a/packages/preset-mini/src/variants/breakpoints.ts b/packages/preset-mini/src/variants/breakpoints.ts
index e865e0592b..a2e208fb87 100644
--- a/packages/preset-mini/src/variants/breakpoints.ts
+++ b/packages/preset-mini/src/variants/breakpoints.ts
@@ -4,7 +4,7 @@ import type { Theme } from '../theme'
 
 const regexCache: Record<string, RegExp> = {}
 
-const calcMaxWidthBySize = (size: string) => {
+export const calcMaxWidthBySize = (size: string) => {
   const value = size.match(/^-?[0-9]+\.?[0-9]*/)?.[0] || ''
   const unit = size.slice(value.length)
   const maxWidth = (parseFloat(value) - 0.1)
diff --git a/packages/transformer-directives/src/index.ts b/packages/transformer-directives/src/index.ts
index 3431ed1a83..939343acee 100644
--- a/packages/transformer-directives/src/index.ts
+++ b/packages/transformer-directives/src/index.ts
@@ -1,8 +1,10 @@
 import { cssIdRE, expandVariantGroup, notNull, regexScopePlaceholder } from '@unocss/core'
 import type { SourceCodeTransformer, StringifiedUtil, UnoGenerator } from '@unocss/core'
-import type { CssNode, Declaration, List, ListItem, Rule, Selector, SelectorList } from 'css-tree'
+import type { Atrule, CssNode, Declaration, List, ListItem, Rule, Selector, SelectorList } from 'css-tree'
 import { clone, generate, parse, walk } from 'css-tree'
 import type MagicString from 'magic-string'
+import { calcMaxWidthBySize } from '@unocss/preset-mini/variants'
+import type { Theme } from '@unocss/preset-mini'
 
 type Writeable<T> = { -readonly [P in keyof T]: T[P] }
 
@@ -37,6 +39,7 @@ export default function transformerDirectives(options: TransformerDirectivesOpti
 }
 
 const themeFnRE = /theme\((.*?)\)/g
+const screenRuleRE = /(@screen) (.+) /g
 
 export async function transformDirectives(
   code: MagicString,
@@ -52,9 +55,10 @@ export async function transformDirectives(
   } = options
 
   const isApply = code.original.includes('@apply') || (varStyle !== false && code.original.includes(varStyle))
+  const isScreen = code.original.includes('@screen')
   const hasThemeFn = code.original.match(themeFnRE)
 
-  if (!isApply && !hasThemeFn)
+  if (!isApply && !hasThemeFn && !isScreen)
     return
 
   const ast = parse(originalCode || code.original, {
@@ -187,9 +191,69 @@ export async function transformDirectives(
     }
   }
 
+  const handleScreen = (node: Atrule) => {
+    let breakpointName = ''; let prefix
+    if (node.name === 'screen' && node.prelude?.type === 'Raw')
+      breakpointName = node.prelude.value.trim()
+
+    if (!breakpointName)
+      return
+
+    const match = breakpointName.match(/^(?:(lt|at)-)?(\w+)$/)
+    if (match) {
+      prefix = match[1]
+      breakpointName = match[2]
+    }
+
+    const resolveBreakpoints = () => {
+      let breakpoints: Record<string, string> | undefined
+      if (uno.userConfig && uno.userConfig.theme)
+        breakpoints = (uno.userConfig.theme as Theme).breakpoints
+
+      if (!breakpoints)
+        breakpoints = (uno.config.theme as Theme).breakpoints
+
+      return breakpoints
+    }
+    const variantEntries: Array<[string, string, number]> = Object.entries(resolveBreakpoints() ?? {}).map(([point, size], idx) => [point, size, idx])
+    const generateMediaQuery = (breakpointName: string, prefix?: string) => {
+      const [, size, idx] = variantEntries.find(i => i[0] === breakpointName)!
+      if (prefix) {
+        if (prefix === 'lt')
+          return `@media (max-width: ${calcMaxWidthBySize(size)})`
+        else if (prefix === 'at')
+          return `@media (min-width: ${size})${variantEntries[idx + 1] ? ` and (max-width: ${calcMaxWidthBySize(variantEntries[idx + 1][1])})` : ''}`
+
+        else throw new Error(`breakpoint variant not surpported: ${prefix}`)
+      }
+      return `@media (min-width: ${size})`
+    }
+
+    if (!variantEntries.find(i => i[0] === breakpointName))
+      throw new Error(`breakpoint ${breakpointName} not found`)
+
+    const offset = node.loc!.start.offset
+    const str = code.original.slice(offset, node.loc!.end.offset)
+    const matches = Array.from(str.matchAll(screenRuleRE))
+
+    if (!matches.length)
+      return
+
+    for (const match of matches) {
+      code.overwrite(
+        offset + match.index!,
+        offset + match.index! + match[0].length,
+        `${generateMediaQuery(breakpointName, prefix)} `,
+      )
+    }
+  }
+
   const stack: Promise<void>[] = []
 
   const processNode = async (node: CssNode, _item: ListItem<CssNode>, _list: List<CssNode>) => {
+    if (isScreen && node.type === 'Atrule')
+      handleScreen(node)
+
     if (hasThemeFn && node.type === 'Declaration')
       handleThemeFn(node)
 
diff --git a/test/transformer-directives.test.ts b/test/transformer-directives.test.ts
index 9eba468348..9eb15f6a67 100644
--- a/test/transformer-directives.test.ts
+++ b/test/transformer-directives.test.ts
@@ -18,6 +18,16 @@ describe('transformer-directives', () => {
     shortcuts: {
       btn: 'px-2 py-3 md:px-4 bg-blue-500 text-white rounded',
     },
+    theme: {
+      breakpoints: {
+        xs: '320px',
+        sm: '640px',
+        md: '768px',
+        lg: '1024px',
+        xl: '1280px',
+        xxl: '1536px',
+      },
+    },
   })
 
   async function transform(code: string, _uno: UnoGenerator = uno) {
@@ -296,26 +306,7 @@ describe('transformer-directives', () => {
   })
 
   test('custom breakpoints', async () => {
-    const customUno = createGenerator({
-      presets: [
-        presetUno(),
-      ],
-      theme: {
-        breakpoints: {
-          'xs': '320px',
-          'sm': '640px',
-          'md': '768px',
-          'lg': '1024px',
-          'xl': '1280px',
-          '2xl': '1536px',
-          'xxl': '1536px',
-        },
-      },
-    })
-    const result = await transform(
-      '.grid { @apply grid grid-cols-2 xs:grid-cols-1 xxl:grid-cols-15 xl:grid-cols-10 sm:grid-cols-7 md:grid-cols-3 lg:grid-cols-4 }',
-      customUno,
-    )
+    const result = await transform('.grid { @apply grid grid-cols-2 xs:grid-cols-1 xxl:grid-cols-15 xl:grid-cols-10 sm:grid-cols-7 md:grid-cols-3 lg:grid-cols-4 }')
     expect(result)
       .toMatchInlineSnapshot(`
         ".grid {
@@ -396,10 +387,176 @@ describe('transformer-directives', () => {
       `)
   })
 
+  test('@screen basic', async () => {
+    const result = await transform(`
+          .grid {
+            @apply grid grid-cols-2;
+          }
+          @screen xs {
+            .grid {
+              @apply grid-cols-1;
+            }
+          }
+          @screen sm {
+            .grid {
+              @apply grid-cols-3;
+            }
+          }
+          @screen md {
+            .grid {
+              @apply grid-cols-4;
+            }
+          }
+          @screen lg {
+            .grid {
+              @apply grid-cols-5;
+            }
+          }
+          @screen xl {
+            .grid {
+              @apply grid-cols-6;
+            }
+          }
+          @screen xxl {
+            .grid {
+              @apply grid-cols-7;
+            }
+          }
+        `)
+    expect(result)
+      .toMatchInlineSnapshot(`
+          ".grid {
+            display: grid;
+            grid-template-columns: repeat(2, minmax(0, 1fr));
+          }
+          @media (min-width: 320px) {
+            .grid {
+              grid-template-columns: repeat(1, minmax(0, 1fr));
+            }
+          }
+          @media (min-width: 640px) {
+            .grid {
+              grid-template-columns: repeat(3, minmax(0, 1fr));
+            }
+          }
+          @media (min-width: 768px) {
+            .grid {
+              grid-template-columns: repeat(4, minmax(0, 1fr));
+            }
+          }
+          @media (min-width: 1024px) {
+            .grid {
+              grid-template-columns: repeat(5, minmax(0, 1fr));
+            }
+          }
+          @media (min-width: 1280px) {
+            .grid {
+              grid-template-columns: repeat(6, minmax(0, 1fr));
+            }
+          }
+          @media (min-width: 1536px) {
+            .grid {
+              grid-template-columns: repeat(7, minmax(0, 1fr));
+            }
+          }
+          "
+        `)
+  })
+
+  test('@screen lt variant', async () => {
+    const result = await transform(`
+          .grid {
+            @apply grid grid-cols-2;
+          }
+          @screen lt-xs {
+            .grid {
+              @apply grid-cols-1;
+            }
+          }
+          @screen lt-sm {
+            .grid {
+              @apply grid-cols-3;
+            }
+          }
+          @screen lt-md {
+            .grid {
+              @apply grid-cols-4;
+            }
+          }
+        `)
+    expect(result).toMatchInlineSnapshot(`
+        ".grid {
+          display: grid;
+          grid-template-columns: repeat(2, minmax(0, 1fr));
+        }
+        @media (max-width: 319.9px) {
+          .grid {
+            grid-template-columns: repeat(1, minmax(0, 1fr));
+          }
+        }
+        @media (max-width: 639.9px) {
+          .grid {
+            grid-template-columns: repeat(3, minmax(0, 1fr));
+          }
+        }
+        @media (max-width: 767.9px) {
+          .grid {
+            grid-template-columns: repeat(4, minmax(0, 1fr));
+          }
+        }
+        "
+      `)
+  })
+
+  test('@screen at variant', async () => {
+    const result = await transform(`
+          .grid {
+            @apply grid grid-cols-2;
+          }
+          @screen at-xs {
+            .grid {
+              @apply grid-cols-1;
+            }
+          }
+          @screen at-xl {
+            .grid {
+              @apply grid-cols-3;
+            }
+          }
+          @screen at-xxl {
+            .grid {
+              @apply grid-cols-4;
+            }
+          }
+        `)
+    expect(result).toMatchInlineSnapshot(`
+      ".grid {
+        display: grid;
+        grid-template-columns: repeat(2, minmax(0, 1fr));
+      }
+      @media (min-width: 320px) and (max-width: 639.9px) {
+        .grid {
+          grid-template-columns: repeat(1, minmax(0, 1fr));
+        }
+      }
+      @media (min-width: 1280px) and (max-width: 1535.9px) {
+        .grid {
+          grid-template-columns: repeat(3, minmax(0, 1fr));
+        }
+      }
+      @media (min-width: 1536px) {
+        .grid {
+          grid-template-columns: repeat(4, minmax(0, 1fr));
+        }
+      }
+      "
+    `)
+  })
+
   describe('theme()', () => {
     test('basic', async () => {
       const result = await transform(
-        `.btn { 
+        `.btn {
           background-color: theme("colors.blue.500");
           padding: theme("spacing.xs") theme("spacing.sm");
         }
@@ -422,14 +579,14 @@ describe('transformer-directives', () => {
 
     test('non-exist', async () => {
       expect(async () => await transform(
-        `.btn { 
+        `.btn {
         color: theme("color.none.500");
         }`,
       )).rejects
         .toMatchInlineSnapshot('[Error: theme of "color.none.500" did not found]')
 
       expect(async () => await transform(
-          `.btn { 
+          `.btn {
           font-size: theme("size.lg");
           }`,
       )).rejects
@@ -438,7 +595,7 @@ describe('transformer-directives', () => {
 
     test('args', async () => {
       expect(async () => await transform(
-        `.btn { 
+        `.btn {
           color: theme();
         }`,
       )).rejects