diff --git a/docs/config/index.md b/docs/config/index.md
index e980f7ef1dd83a..e7043a5145cc30 100644
--- a/docs/config/index.md
+++ b/docs/config/index.md
@@ -415,7 +415,7 @@ export default defineConfig(async ({ command, mode }) => {
           changeOrigin: true,
           configure: (proxy, options) => {
             // proxy will be an instance of 'http-proxy'
-          },
+          }
         }
       }
     }
@@ -741,9 +741,9 @@ SSR options may be adjusted in minor releases.
 
 ### ssr.noExternal
 
-- **Type:** `string | RegExp | (string | RegExp)[]`
+- **Type:** `string | RegExp | (string | RegExp)[] | true`
 
-  Prevent listed dependencies from being externalized for SSR.
+  Prevent listed dependencies from being externalized for SSR. If `true`, no dependencies are externalized.
 
 ### ssr.target
 
diff --git a/docs/guide/ssr.md b/docs/guide/ssr.md
index 7a7b5673e7a1f3..3d65723a6bfc58 100644
--- a/docs/guide/ssr.md
+++ b/docs/guide/ssr.md
@@ -251,3 +251,10 @@ export function mySSRPlugin() {
 ## SSR Target
 
 The default target for the SSR build is a node environment, but you can also run the server in a Web Worker. Packages entry resolution is different for each platform. You can configure the target to be Web Worker using the `ssr.target` set to `'webworker'`.
+
+## SSR Bundle
+
+In some cases like `webworker` runtimes, you might want to bundle your SSR build into a single JavaScript file. You can enable this behavior by setting `ssr.noExternal` to `true`. This will do two things:
+
+- Treat all dependencies as `noExternal`
+- Throw an error if any Node.js built-ins are imported
diff --git a/packages/playground/ssr-webworker/__tests__/serve.js b/packages/playground/ssr-webworker/__tests__/serve.js
new file mode 100644
index 00000000000000..f4f207b85026c6
--- /dev/null
+++ b/packages/playground/ssr-webworker/__tests__/serve.js
@@ -0,0 +1,48 @@
+// @ts-check
+// this is automtically detected by scripts/jestPerTestSetup.ts and will replace
+// the default e2e test serve behavior
+
+const path = require('path')
+
+const port = (exports.port = 9528)
+
+/**
+ * @param {string} root
+ * @param {boolean} isProd
+ */
+exports.serve = async function serve(root, isProd) {
+  // we build first, regardless of whether it's prod/build mode
+  // because Vite doesn't support the concept of a "webworker server"
+  const { build } = require('vite')
+
+  // worker build
+  await build({
+    root,
+    logLevel: 'silent',
+    build: {
+      target: 'esnext',
+      ssr: 'src/entry-worker.jsx',
+      outDir: 'dist/worker'
+    }
+  })
+
+  const { createServer } = require(path.resolve(root, 'worker.js'))
+  const { app } = await createServer(root, isProd)
+
+  return new Promise((resolve, reject) => {
+    try {
+      const server = app.listen(port, () => {
+        resolve({
+          // for test teardown
+          async close() {
+            await new Promise((resolve) => {
+              server.close(resolve)
+            })
+          }
+        })
+      })
+    } catch (e) {
+      reject(e)
+    }
+  })
+}
diff --git a/packages/playground/ssr-webworker/__tests__/ssr-webworker.spec.ts b/packages/playground/ssr-webworker/__tests__/ssr-webworker.spec.ts
new file mode 100644
index 00000000000000..30d2bb93e495b1
--- /dev/null
+++ b/packages/playground/ssr-webworker/__tests__/ssr-webworker.spec.ts
@@ -0,0 +1,10 @@
+import { port } from './serve'
+
+const url = `http://localhost:${port}`
+
+test('/', async () => {
+  await page.goto(url + '/')
+  expect(await page.textContent('h1')).toMatch('hello from webworker')
+  expect(await page.textContent('.linked')).toMatch('dep from upper directory')
+  expect(await page.textContent('.external')).toMatch('object')
+})
diff --git a/packages/playground/ssr-webworker/package.json b/packages/playground/ssr-webworker/package.json
new file mode 100644
index 00000000000000..b37e403b658522
--- /dev/null
+++ b/packages/playground/ssr-webworker/package.json
@@ -0,0 +1,15 @@
+{
+  "name": "test-ssr-webworker",
+  "private": true,
+  "version": "0.0.0",
+  "scripts": {
+    "dev": "DEV=1 node worker",
+    "build:worker": "vite build --ssr src/entry-worker.jsx --outDir dist/worker"
+  },
+  "dependencies": {
+    "react": "^17.0.2"
+  },
+  "devDependencies": {
+    "miniflare": "^1.3.3"
+  }
+}
diff --git a/packages/playground/ssr-webworker/src/entry-worker.jsx b/packages/playground/ssr-webworker/src/entry-worker.jsx
new file mode 100644
index 00000000000000..c885657b18a6d3
--- /dev/null
+++ b/packages/playground/ssr-webworker/src/entry-worker.jsx
@@ -0,0 +1,19 @@
+import { msg as linkedMsg } from 'resolve-linked'
+import React from 'react'
+
+addEventListener('fetch', function (event) {
+  return event.respondWith(
+    new Response(
+      `
+    <h1>hello from webworker</h1>
+    <p class="linked">${linkedMsg}</p>
+    <p class="external">${typeof React}</p>
+    `,
+      {
+        headers: {
+          'content-type': 'text/html'
+        }
+      }
+    )
+  )
+})
diff --git a/packages/playground/ssr-webworker/vite.config.js b/packages/playground/ssr-webworker/vite.config.js
new file mode 100644
index 00000000000000..d0e80179498685
--- /dev/null
+++ b/packages/playground/ssr-webworker/vite.config.js
@@ -0,0 +1,12 @@
+/**
+ * @type {import('vite').UserConfig}
+ */
+module.exports = {
+  build: {
+    minify: false
+  },
+  ssr: {
+    target: 'webworker',
+    noExternal: true
+  }
+}
diff --git a/packages/playground/ssr-webworker/worker.js b/packages/playground/ssr-webworker/worker.js
new file mode 100644
index 00000000000000..09725aaa9d71bb
--- /dev/null
+++ b/packages/playground/ssr-webworker/worker.js
@@ -0,0 +1,26 @@
+// @ts-check
+const path = require('path')
+const { Miniflare } = require('miniflare')
+
+const isDev = process.env.DEV
+
+async function createServer(root = process.cwd()) {
+  const mf = new Miniflare({
+    scriptPath: path.resolve(root, 'dist/worker/entry-worker.js')
+  })
+
+  const app = mf.createServer()
+
+  return { app }
+}
+
+if (isDev) {
+  createServer().then(({ app }) =>
+    app.listen(3000, () => {
+      console.log('http://localhost:3000')
+    })
+  )
+}
+
+// for test use
+exports.createServer = createServer
diff --git a/packages/vite/src/node/config.ts b/packages/vite/src/node/config.ts
index fb8c3a5bba0aac..cd1d801fb8388d 100644
--- a/packages/vite/src/node/config.ts
+++ b/packages/vite/src/node/config.ts
@@ -187,7 +187,7 @@ export type SSRTarget = 'node' | 'webworker'
 
 export interface SSROptions {
   external?: string[]
-  noExternal?: string | RegExp | (string | RegExp)[]
+  noExternal?: string | RegExp | (string | RegExp)[] | true
   /**
    * Define the target for the ssr build. The browser field in package.json
    * is ignored for node but used if webworker is the target
@@ -383,7 +383,7 @@ export async function resolveConfig(
                 root: resolvedRoot,
                 isProduction,
                 isBuild: command === 'build',
-                ssrTarget: resolved.ssr?.target,
+                ssrConfig: resolved.ssr,
                 asSrc: true,
                 preferRelative: false,
                 tryIndex: true,
diff --git a/packages/vite/src/node/plugins/index.ts b/packages/vite/src/node/plugins/index.ts
index a83ddae2b2bf2a..6c88978f437ccf 100644
--- a/packages/vite/src/node/plugins/index.ts
+++ b/packages/vite/src/node/plugins/index.ts
@@ -39,7 +39,7 @@ export async function resolvePlugins(
       root: config.root,
       isProduction: config.isProduction,
       isBuild,
-      ssrTarget: config.ssr?.target,
+      ssrConfig: config.ssr,
       asSrc: true
     }),
     htmlInlineScriptProxyPlugin(),
diff --git a/packages/vite/src/node/plugins/resolve.ts b/packages/vite/src/node/plugins/resolve.ts
index d9cb8b14b70980..dfaa270e79050f 100644
--- a/packages/vite/src/node/plugins/resolve.ts
+++ b/packages/vite/src/node/plugins/resolve.ts
@@ -25,7 +25,7 @@ import {
   cleanUrl,
   slash
 } from '../utils'
-import { ViteDevServer, SSRTarget } from '..'
+import { ViteDevServer, SSROptions } from '..'
 import { createFilter } from '@rollup/pluginutils'
 import { PartialResolvedId } from 'rollup'
 import { resolve as _resolveExports } from 'resolve.exports'
@@ -50,7 +50,7 @@ export interface InternalResolveOptions extends ResolveOptions {
   root: string
   isBuild: boolean
   isProduction: boolean
-  ssrTarget?: SSRTarget
+  ssrConfig?: SSROptions
   /**
    * src code mode also attempts the following:
    * - resolving /xxx as URLs
@@ -69,7 +69,7 @@ export function resolvePlugin(baseOptions: InternalResolveOptions): Plugin {
     root,
     isProduction,
     asSrc,
-    ssrTarget,
+    ssrConfig,
     preferRelative = false
   } = baseOptions
   const requireOptions: InternalResolveOptions = {
@@ -78,6 +78,8 @@ export function resolvePlugin(baseOptions: InternalResolveOptions): Plugin {
   }
   let server: ViteDevServer | undefined
 
+  const { target: ssrTarget, noExternal: ssrNoExternal } = ssrConfig ?? {}
+
   return {
     name: 'vite:resolve',
 
@@ -224,6 +226,18 @@ export function resolvePlugin(baseOptions: InternalResolveOptions): Plugin {
         // externalize if building for SSR, otherwise redirect to empty module
         if (isBuiltin(id)) {
           if (ssr) {
+            if (ssrNoExternal === true) {
+              let message = `Cannot bundle Node.js built-in "${id}"`
+              if (importer) {
+                message += ` imported from "${path.relative(
+                  process.cwd(),
+                  importer
+                )}"`
+              }
+              message += `. Consider disabling ssr.noExternal or remove the built-in dependency.`
+              this.error(message)
+            }
+
             return {
               id,
               external: true
diff --git a/packages/vite/src/node/ssr/ssrExternal.ts b/packages/vite/src/node/ssr/ssrExternal.ts
index a3481283038789..4c3b40e1915a9a 100644
--- a/packages/vite/src/node/ssr/ssrExternal.ts
+++ b/packages/vite/src/node/ssr/ssrExternal.ts
@@ -18,6 +18,10 @@ export function resolveSSRExternal(
   ssrExternals: Set<string> = new Set(),
   seen: Set<string> = new Set()
 ): string[] {
+  if (config.ssr?.noExternal === true) {
+    return []
+  }
+
   const { root } = config
   const pkgContent = lookupFile(root, ['package.json'])
   if (!pkgContent) {