diff --git a/packages/vite/src/node/utils.ts b/packages/vite/src/node/utils.ts
index c0bc0646f58336..23c7597bb77195 100644
--- a/packages/vite/src/node/utils.ts
+++ b/packages/vite/src/node/utils.ts
@@ -951,12 +951,17 @@ export const requireResolveFromRootWithFallback = (
   root: string,
   id: string
 ): string => {
+  const paths = _require.resolve.paths?.(id) || []
   // Search in the root directory first, and fallback to the default require paths.
-  const fallbackPaths = _require.resolve.paths?.(id) || []
-  const path = _require.resolve(id, {
-    paths: [root, ...fallbackPaths]
-  })
-  return path
+  paths.unshift(root)
+
+  // Use `resolve` package to check existence first, so if the package is not found,
+  // it won't be cached by nodejs, since there isn't a way to invalidate them:
+  // https://github.com/nodejs/node/issues/44663
+  resolve.sync(id, { basedir: root, paths })
+
+  // Use `require.resolve` again as the `resolve` package doesn't support the `exports` field
+  return _require.resolve(id, { paths })
 }
 
 // Based on node-graceful-fs