diff --git a/packages/vite/src/client/overlay.ts b/packages/vite/src/client/overlay.ts
index 57171b7ec13c0b..91ad9cc6fb95df 100644
--- a/packages/vite/src/client/overlay.ts
+++ b/packages/vite/src/client/overlay.ts
@@ -178,6 +178,7 @@ export class ErrorOverlay extends HTMLElement {
     } else {
       let curIndex = 0
       let match: RegExpExecArray | null
+      fileRE.lastIndex = 0
       while ((match = fileRE.exec(text))) {
         const { 0: file, index } = match
         if (index != null) {
diff --git a/packages/vite/src/node/optimizer/scan.ts b/packages/vite/src/node/optimizer/scan.ts
index 891be702cb6bb2..106a8358d2f327 100644
--- a/packages/vite/src/node/optimizer/scan.ts
+++ b/packages/vite/src/node/optimizer/scan.ts
@@ -534,11 +534,8 @@ function extractImportPaths(code: string) {
 
   let js = ''
   let m
+  importsRE.lastIndex = 0
   while ((m = importsRE.exec(code)) != null) {
-    // This is necessary to avoid infinite loops with zero-width matches
-    if (m.index === importsRE.lastIndex) {
-      importsRE.lastIndex++
-    }
     js += `\nimport ${m[1]}`
   }
   return js
diff --git a/packages/vite/src/node/plugins/asset.ts b/packages/vite/src/node/plugins/asset.ts
index 1e8b6303488fc3..2a16487a26bbc4 100644
--- a/packages/vite/src/node/plugins/asset.ts
+++ b/packages/vite/src/node/plugins/asset.ts
@@ -72,6 +72,7 @@ export function renderAssetUrlInJS(
 
   // In both cases, the wrapping should already be fine
 
+  assetUrlRE.lastIndex = 0
   while ((match = assetUrlRE.exec(code))) {
     s ||= new MagicString(code)
     const [full, referenceId, postfix = ''] = match
@@ -96,6 +97,7 @@ export function renderAssetUrlInJS(
   // Replace __VITE_PUBLIC_ASSET__5aa0ddc0__ with absolute paths
 
   const publicAssetUrlMap = publicAssetUrlCache.get(config)!
+  publicAssetUrlRE.lastIndex = 0
   while ((match = publicAssetUrlRE.exec(code))) {
     s ||= new MagicString(code)
     const [full, hash] = match
diff --git a/packages/vite/src/node/plugins/html.ts b/packages/vite/src/node/plugins/html.ts
index 0561d305447f00..c9094ba6093d6e 100644
--- a/packages/vite/src/node/plugins/html.ts
+++ b/packages/vite/src/node/plugins/html.ts
@@ -398,6 +398,7 @@ export function buildHtmlPlugin(config: ResolvedConfig): Plugin {
               const cleanCode = stripLiteral(scriptNode.value)
 
               let match: RegExpExecArray | null
+              inlineImportRE.lastIndex = 0
               while ((match = inlineImportRE.exec(cleanCode))) {
                 const { 1: url, index } = match
                 const startUrl = cleanCode.indexOf(url, index)
@@ -779,6 +780,7 @@ export function buildHtmlPlugin(config: ResolvedConfig): Plugin {
         // no use assets plugin because it will emit file
         let match: RegExpExecArray | null
         let s: MagicString | undefined
+        inlineCSSRE.lastIndex = 0
         while ((match = inlineCSSRE.exec(result))) {
           s ||= new MagicString(result)
           const { 0: full, 1: scopedName } = match
diff --git a/packages/vite/src/node/plugins/worker.ts b/packages/vite/src/node/plugins/worker.ts
index 9c3dc54654e2dd..ae13e60a052e62 100644
--- a/packages/vite/src/node/plugins/worker.ts
+++ b/packages/vite/src/node/plugins/worker.ts
@@ -336,6 +336,7 @@ export function webWorkerPlugin(config: ResolvedConfig): Plugin {
 
         let match: RegExpExecArray | null
         s = new MagicString(code)
+        workerAssetUrlRE.lastIndex = 0
 
         // Replace "__VITE_WORKER_ASSET__5aa0ddc0__" using relative paths
         const workerMap = workerCache.get(config.mainConfig || config)!