diff --git a/packages/vite/src/node/plugins/esbuild.ts b/packages/vite/src/node/plugins/esbuild.ts
index 9fd20151de8365..6ed963a5d5981c 100644
--- a/packages/vite/src/node/plugins/esbuild.ts
+++ b/packages/vite/src/node/plugins/esbuild.ts
@@ -182,7 +182,11 @@ export function esbuildPlugin(options: ESBuildOptions = {}): Plugin {
     minifyIdentifiers: false,
     minifySyntax: false,
     minifyWhitespace: false,
-    treeShaking: false
+    treeShaking: false,
+    // keepNames is not needed when minify is disabled.
+    // Also transforming multiple times with keepNames enabled breaks
+    // tree-shaking. (#9164)
+    keepNames: false
   }
 
   return {