diff --git a/packages/vite/src/node/__tests__/cleanString.spec.ts b/packages/vite/src/node/__tests__/cleanString.spec.ts
index b77f4c0fb5fbad..f307c4816b7cd3 100644
--- a/packages/vite/src/node/__tests__/cleanString.spec.ts
+++ b/packages/vite/src/node/__tests__/cleanString.spec.ts
@@ -1,3 +1,4 @@
+import { assetAttrsConfig } from './../plugins/html'
 import { emptyString } from '../../node/cleanString'
 
 test('comments', () => {
@@ -51,6 +52,16 @@ test('escape character', () => {
   expect(clean).not.toMatch('1')
 })
 
+test('regexp affect', () => {
+  const clean = emptyString(`
+    /'/
+    '1'
+    /"/
+    "1"
+  `)
+  expect(clean).not.toMatch('1')
+})
+
 test('strings comment nested', () => {
   expect(
     emptyString(`
diff --git a/packages/vite/src/node/cleanString.ts b/packages/vite/src/node/cleanString.ts
index 2b7cba41aef66b..3d623dce79c0d3 100644
--- a/packages/vite/src/node/cleanString.ts
+++ b/packages/vite/src/node/cleanString.ts
@@ -2,8 +2,9 @@ import type { RollupError } from 'rollup'
 // bank on the non-overlapping nature of regex matches and combine all filters into one giant regex
 // /`([^`\$\{\}]|\$\{(`|\g<1>)*\})*`/g can match nested string template
 // but js not support match expression(\g<0>). so clean string template(`...`) in other ways.
-const cleanerRE =
-  /"([^"]|(?<=\\)")*"|'([^']|(?<=\\)')*'|\/\*(.|[\r\n])*?\*\/|\/\/.*/g
+const stringsRE = /"([^"\r\n]|(?<=\\)")*"|'([^'\r\n]|(?<=\\)')*'/.source
+const commentsRE = /\/\*(.|[\r\n])*?\*\/|\/\/.*/.source
+const cleanerRE = new RegExp(`${stringsRE}|${commentsRE}`, 'g')
 
 const blankReplacer = (s: string) => ' '.repeat(s.length)
 const stringBlankReplacer = (s: string) =>