diff --git a/docs/config/server-options.md b/docs/config/server-options.md
index d216bbed486fca..f10cca7ce1db61 100644
--- a/docs/config/server-options.md
+++ b/docs/config/server-options.md
@@ -318,3 +318,22 @@ export default defineConfig({
   },
 })
 ```
+
+## server.sourcemapIgnoreList
+
+- **Type:** `false | (sourcePath: string, sourcemapPath: string) => boolean`
+- **Default:** `(sourcePath) => sourcePath.includes('node_modules')`
+
+Whether or not to ignore source files in the server sourcemap, used to populate the [`x_google_ignoreList` source map extension](https://developer.chrome.com/blog/devtools-better-angular-debugging/#the-x_google_ignorelist-source-map-extension).
+
+By default, it excludes all paths containing `node_modules`. You can pass `false` to disable this behavior, or, for full control, a function that takes the source path and sourcemap path and returns whether to ignore the source path.
+
+```js
+export default defineConfig({
+  server: {
+    // This is the default value, and will add all files with node_modules in their paths
+    // to the ignore list.
+    sourcemapIgnoreList: (sourcePath, sourcemapPath) => sourcePath.includes('node_modules')
+  }
+};
+```
diff --git a/packages/vite/src/node/server/index.ts b/packages/vite/src/node/server/index.ts
index d90761c6dfed9e..0edf8692835375 100644
--- a/packages/vite/src/node/server/index.ts
+++ b/packages/vite/src/node/server/index.ts
@@ -115,6 +115,17 @@ export interface ServerOptions extends CommonServerOptions {
    * @default true
    */
   preTransformRequests?: boolean
+  /**
+   * Whether or not to ignore-list source files in the dev server sourcemap, used to populate
+   * the [`x_google_ignoreList` source map extension](https://developer.chrome.com/blog/devtools-better-angular-debugging/#the-x_google_ignorelist-source-map-extension).
+   *
+   * By default, it excludes all paths containing `node_modules`. You can pass `false` to
+   * disable this behavior, or, for full control, a function that takes the source path and
+   * sourcemap path and returns whether to ignore the source path.
+   */
+  sourcemapIgnoreList?:
+    | false
+    | ((sourcePath: string, sourcemapPath: string) => boolean)
   /**
    * Force dep pre-optimization regardless of whether deps have changed.
    *
@@ -127,6 +138,10 @@ export interface ServerOptions extends CommonServerOptions {
 export interface ResolvedServerOptions extends ServerOptions {
   fs: Required<FileSystemServeOptions>
   middlewareMode: boolean
+  sourcemapIgnoreList: Exclude<
+    ServerOptions['sourcemapIgnoreList'],
+    false | undefined
+  >
 }
 
 export interface FileSystemServeOptions {
@@ -746,7 +761,12 @@ export function resolveServerOptions(
 ): ResolvedServerOptions {
   const server: ResolvedServerOptions = {
     preTransformRequests: true,
-    ...(raw as ResolvedServerOptions),
+    ...(raw as Omit<ResolvedServerOptions, 'sourcemapIgnoreList'>),
+    sourcemapIgnoreList:
+      raw?.sourcemapIgnoreList === false
+        ? () => false
+        : raw?.sourcemapIgnoreList ||
+          ((sourcePath) => sourcePath.includes('node_modules')),
     middlewareMode: !!raw?.middlewareMode,
   }
   let allowDirs = server.fs?.allow
diff --git a/packages/vite/src/node/server/transformRequest.ts b/packages/vite/src/node/server/transformRequest.ts
index 662db957b7cc8d..ec80c852ec41c5 100644
--- a/packages/vite/src/node/server/transformRequest.ts
+++ b/packages/vite/src/node/server/transformRequest.ts
@@ -278,6 +278,23 @@ async function loadAndTransform(
     ) {
       const sourcePath = map.sources[sourcesIndex]
 
+      const sourcemapPath = `${mod.file}.map`
+      const ignoreList = config.server.sourcemapIgnoreList(
+        sourcePath,
+        sourcemapPath,
+      )
+      if (typeof ignoreList !== 'boolean') {
+        logger.warn('sourcemapIgnoreList function must return a boolean.')
+      }
+      if (ignoreList) {
+        if (map.x_google_ignoreList === undefined) {
+          map.x_google_ignoreList = []
+        }
+        if (!map.x_google_ignoreList.includes(sourcesIndex)) {
+          map.x_google_ignoreList.push(sourcesIndex)
+        }
+      }
+
       // Rewrite sources to relative paths to give debuggers the chance
       // to resolve and display them in a meaningful way (rather than
       // with absolute paths).