diff --git a/packages/vite/package.json b/packages/vite/package.json
index e6e5e3e850c2c9..f4f254bb6b1c22 100644
--- a/packages/vite/package.json
+++ b/packages/vite/package.json
@@ -113,7 +113,7 @@
     "source-map-support": "^0.5.21",
     "strip-ansi": "^6.0.1",
     "terser": "^5.10.0",
-    "tsconfck": "1.1.2",
+    "tsconfck": "^1.2.0",
     "tslib": "^2.3.1",
     "types": "link:./types",
     "ws": "^8.5.0"
diff --git a/packages/vite/src/node/plugins/esbuild.ts b/packages/vite/src/node/plugins/esbuild.ts
index e0a7f884e000be..f0e25945828f49 100644
--- a/packages/vite/src/node/plugins/esbuild.ts
+++ b/packages/vite/src/node/plugins/esbuild.ts
@@ -20,8 +20,9 @@ import type { SourceMap } from 'rollup'
 import type { ResolvedConfig, ViteDevServer } from '..'
 import { createFilter } from '@rollup/pluginutils'
 import { combineSourcemaps } from '../utils'
-import type { TSConfckParseResult } from 'tsconfck'
-import { parse, TSConfckParseError } from 'tsconfck'
+import type { TSConfckParseOptions, TSConfckParseResult } from 'tsconfck'
+import { parse, findAll, TSConfckParseError } from 'tsconfck'
+import { searchForWorkspaceRoot } from '..'
 
 const debug = createDebugger('vite:esbuild')
 
@@ -179,6 +180,9 @@ export function esbuildPlugin(options: ESBuildOptions = {}): Plugin {
         .on('change', reloadOnTsconfigChange)
         .on('unlink', reloadOnTsconfigChange)
     },
+    async configResolved(config) {
+      await initTSConfck(config)
+    },
     buildEnd() {
       // recycle serve to avoid preventing Node self-exit (#6815)
       server = null as any
@@ -224,6 +228,9 @@ const rollupToEsbuildFormatMap: Record<
 export const buildEsbuildPlugin = (config: ResolvedConfig): Plugin => {
   return {
     name: 'vite:esbuild-transpile',
+    async configResolved(config) {
+      await initTSConfck(config)
+    },
     async renderChunk(code, chunk, opts) {
       // @ts-ignore injected by @vitejs/plugin-legacy
       if (opts.__vite_skip_esbuild__) {
@@ -274,15 +281,29 @@ function prettifyMessage(m: Message, code: string): string {
   return res + `\n`
 }
 
-const tsconfigCache = new Map<string, TSConfckParseResult>()
+const tsconfckParseOptions: TSConfckParseOptions = {
+  cache: new Map<string, TSConfckParseResult>(),
+  tsConfigPaths: undefined,
+  root: undefined,
+  resolveWithEmptyIfConfigNotFound: true
+}
+
+async function initTSConfck(config: ResolvedConfig) {
+  tsconfckParseOptions.cache!.clear()
+  const workspaceRoot = searchForWorkspaceRoot(config.root)
+  tsconfckParseOptions.root = workspaceRoot
+  tsconfckParseOptions.tsConfigPaths = new Set([
+    ...(await findAll(workspaceRoot, {
+      skip: (dir) => dir === 'node_modules' || dir === '.git'
+    }))
+  ])
+}
+
 async function loadTsconfigJsonForFile(
   filename: string
 ): Promise<TSConfigJSON> {
   try {
-    const result = await parse(filename, {
-      cache: tsconfigCache,
-      resolveWithEmptyIfConfigNotFound: true
-    })
+    const result = await parse(filename, tsconfckParseOptions)
     // tsconfig could be out of root, make sure it is watched on dev
     if (server && result.tsconfigFile !== 'no_tsconfig_file_found') {
       ensureWatchedFile(server.watcher, result.tsconfigFile, server.config.root)
@@ -304,20 +325,24 @@ function reloadOnTsconfigChange(changedFile: string) {
   // any json file in the tsconfig cache could have been used to compile ts
   if (
     path.basename(changedFile) === 'tsconfig.json' ||
-    (changedFile.endsWith('.json') && tsconfigCache.has(changedFile))
+    (changedFile.endsWith('.json') &&
+      tsconfckParseOptions?.cache?.has(changedFile))
   ) {
     server.config.logger.info(
       `changed tsconfig file detected: ${changedFile} - Clearing cache and forcing full-reload to ensure typescript is compiled with updated config values.`,
       { clear: server.config.clearScreen, timestamp: true }
     )
-    // clear tsconfig cache so that recompile works with up2date configs
-    tsconfigCache.clear()
+
     // clear module graph to remove code compiled with outdated config
     server.moduleGraph.invalidateAll()
-    // force full reload
-    server.ws.send({
-      type: 'full-reload',
-      path: '*'
+
+    // reset tsconfck so that recompile works with up2date configs
+    initTSConfck(server.config).finally(() => {
+      // force full reload
+      server.ws.send({
+        type: 'full-reload',
+        path: '*'
+      })
     })
   }
 }
diff --git a/pnpm-lock.yaml b/pnpm-lock.yaml
index ab2b4a7833c686..736f012b037db6 100644
--- a/pnpm-lock.yaml
+++ b/pnpm-lock.yaml
@@ -803,7 +803,7 @@ importers:
       source-map-support: ^0.5.21
       strip-ansi: ^6.0.1
       terser: ^5.10.0
-      tsconfck: 1.1.2
+      tsconfck: ^1.2.0
       tslib: ^2.3.1
       types: link:./types
       ws: ^8.5.0
@@ -876,7 +876,7 @@ importers:
       source-map-support: 0.5.21
       strip-ansi: 6.0.1
       terser: 5.10.0_acorn@8.7.0
-      tsconfck: 1.1.2_typescript@4.5.4
+      tsconfck: 1.2.0_typescript@4.5.4
       tslib: 2.3.1
       types: link:types
       ws: 8.5.0
@@ -3103,7 +3103,7 @@ packages:
     resolution: {integrity: sha512-oagLNqpfNv7CvmyMoexMDNyVDSiq1rya0AEUgcLlNHdHgNl6U/hi8xY370n5y+ZIFEXOx0J4B1qF2NDjMRxklA==}
     engines: {node: '>=6.0.0'}
     dependencies:
-      pvutils: 1.0.17
+      pvutils: 1.1.2
     dev: true
 
   /assert-never/1.2.1:
@@ -7690,8 +7690,8 @@ packages:
       tslib: 2.3.1
     dev: true
 
-  /pvutils/1.0.17:
-    resolution: {integrity: sha512-wLHYUQxWaXVQvKnwIDWFVKDJku9XDCvyhhxoq8dc5MFdIlRenyPI9eSfEtcvgHgD7FlvCyGAlWgOzRnZD99GZQ==}
+  /pvutils/1.1.2:
+    resolution: {integrity: sha512-wlo0BUInyP+ZgBJHV8PnJW8S2HubdQfMMip8B9yXr9aFlauJFuF1jZ/RWFmzGYitC7GxkxqXdwbY9/R97v+Cqg==}
     engines: {node: '>=6.0.0'}
     dev: true
 
@@ -8916,8 +8916,8 @@ packages:
       yn: 3.1.1
     dev: true
 
-  /tsconfck/1.1.2_typescript@4.5.4:
-    resolution: {integrity: sha512-n6SkiUQ784Uu2pviyd0j2kspm/fipdjO5jZuR8zUHVVoQeRnR6BSV5zlbheDmpyP0lj7GvHWvFcaxxhUFrzQWQ==}
+  /tsconfck/1.2.0_typescript@4.5.4:
+    resolution: {integrity: sha512-uKBM6x6i5e7Tfof5Zhll2ypgYKwWZhsxsHOoCH/7enlcHjjlcZ8FnxFrqgVFtpN6ymzZX3zoDaVGIlkh/g4x6w==}
     engines: {node: ^12.20 || ^14.13.1 || >= 16}
     hasBin: true
     peerDependencies: