diff --git a/packages/vite/src/node/plugins/completeSystemWrap.ts b/packages/vite/src/node/plugins/completeSystemWrap.ts
index 700166fc5408bf..e1bd6a41f982f5 100644
--- a/packages/vite/src/node/plugins/completeSystemWrap.ts
+++ b/packages/vite/src/node/plugins/completeSystemWrap.ts
@@ -4,7 +4,7 @@ import type { Plugin } from '../plugin'
  * make sure systemjs register wrap to had complete parameters in system format
  */
 export function completeSystemWrapPlugin(): Plugin {
-  const SystemJSWrapRE = /System.register\(.*\((exports)\)/g
+  const SystemJSWrapRE = /System.register\(.*(\(exports\)|\(\))/g
 
   return {
     name: 'vite:force-systemjs-wrap-complete',
@@ -13,7 +13,7 @@ export function completeSystemWrapPlugin(): Plugin {
       if (opts.format === 'system') {
         return {
           code: code.replace(SystemJSWrapRE, (s, s1) =>
-            s.replace(s1, 'exports, module')
+            s.replace(s1, '(exports, module)')
           ),
           map: null
         }