diff --git a/packages/vitest/src/node/plugins/index.ts b/packages/vitest/src/node/plugins/index.ts
index a43dab037c6f..f5d17675a420 100644
--- a/packages/vitest/src/node/plugins/index.ts
+++ b/packages/vitest/src/node/plugins/index.ts
@@ -12,7 +12,7 @@ import { GlobalSetupPlugin } from './globalSetup'
 import { CSSEnablerPlugin } from './cssEnabler'
 import { CoverageTransform } from './coverageTransform'
 import { MocksPlugin } from './mocks'
-import { resolveOptimizerConfig } from './utils'
+import { deleteDefineConfig, resolveOptimizerConfig } from './utils'
 import { VitestResolver } from './vitestResolver'
 
 export async function VitestPlugin(options: UserConfig = {}, ctx = new Vitest('test')): Promise<VitePlugin[]> {
@@ -50,43 +50,11 @@ export async function VitestPlugin(options: UserConfig = {}, ctx = new Vitest('t
         )
         testConfig.api = resolveApiServerConfig(testConfig)
 
-        if (viteConfig.define) {
-          delete viteConfig.define['import.meta.vitest']
-          delete viteConfig.define['process.env']
-        }
-
         // store defines for globalThis to make them
         // reassignable when running in worker in src/runtime/setup.ts
-        const defines: Record<string, any> = {}
-
-        for (const key in viteConfig.define) {
-          const val = viteConfig.define[key]
-          let replacement: any
-          try {
-            replacement = typeof val === 'string' ? JSON.parse(val) : val
-          }
-          catch {
-            // probably means it contains reference to some variable,
-            // like this: "__VAR__": "process.env.VAR"
-            continue
-          }
-          if (key.startsWith('import.meta.env.')) {
-            const envKey = key.slice('import.meta.env.'.length)
-            process.env[envKey] = replacement
-            delete viteConfig.define[key]
-          }
-          else if (key.startsWith('process.env.')) {
-            const envKey = key.slice('process.env.'.length)
-            process.env[envKey] = replacement
-            delete viteConfig.define[key]
-          }
-          else if (!key.includes('.')) {
-            defines[key] = replacement
-            delete viteConfig.define[key]
-          }
-        }
+        const defines: Record<string, any> = deleteDefineConfig(viteConfig)
 
-        (options as ResolvedConfig).defines = defines
+        ;(options as ResolvedConfig).defines = defines
 
         let open: string | boolean | undefined
 
diff --git a/packages/vitest/src/node/plugins/utils.ts b/packages/vitest/src/node/plugins/utils.ts
index 9d1e93f86abe..16a390b7b348 100644
--- a/packages/vitest/src/node/plugins/utils.ts
+++ b/packages/vitest/src/node/plugins/utils.ts
@@ -1,6 +1,6 @@
 import { builtinModules } from 'node:module'
 import { version as viteVersion } from 'vite'
-import type { DepOptimizationOptions } from 'vite'
+import type { DepOptimizationOptions, UserConfig as ViteConfig } from 'vite'
 import type { DepsOptimizationOptions, InlineConfig } from '../../types'
 
 export function resolveOptimizerConfig(testOptionc: DepsOptimizationOptions | undefined, viteOptions: DepOptimizationOptions | undefined, testConfig: InlineConfig) {
@@ -32,3 +32,40 @@ export function resolveOptimizerConfig(testOptionc: DepsOptimizationOptions | un
   }
   return newConfig
 }
+
+export function deleteDefineConfig(viteConfig: ViteConfig) {
+  const defines: Record<string, any> = {}
+  if (viteConfig.define) {
+    delete viteConfig.define['import.meta.vitest']
+    delete viteConfig.define['process.env']
+    delete viteConfig.define.process
+    delete viteConfig.define.global
+  }
+  for (const key in viteConfig.define) {
+    const val = viteConfig.define[key]
+    let replacement: any
+    try {
+      replacement = typeof val === 'string' ? JSON.parse(val) : val
+    }
+    catch {
+      // probably means it contains reference to some variable,
+      // like this: "__VAR__": "process.env.VAR"
+      continue
+    }
+    if (key.startsWith('import.meta.env.')) {
+      const envKey = key.slice('import.meta.env.'.length)
+      process.env[envKey] = replacement
+      delete viteConfig.define[key]
+    }
+    else if (key.startsWith('process.env.')) {
+      const envKey = key.slice('process.env.'.length)
+      process.env[envKey] = replacement
+      delete viteConfig.define[key]
+    }
+    else if (!key.includes('.')) {
+      defines[key] = replacement
+      delete viteConfig.define[key]
+    }
+  }
+  return defines
+}
diff --git a/packages/vitest/src/node/plugins/workspace.ts b/packages/vitest/src/node/plugins/workspace.ts
index f9fd4dda3da7..69340e681afe 100644
--- a/packages/vitest/src/node/plugins/workspace.ts
+++ b/packages/vitest/src/node/plugins/workspace.ts
@@ -10,7 +10,7 @@ import { CSSEnablerPlugin } from './cssEnabler'
 import { EnvReplacerPlugin } from './envReplacer'
 import { GlobalSetupPlugin } from './globalSetup'
 import { MocksPlugin } from './mocks'
-import { resolveOptimizerConfig } from './utils'
+import { deleteDefineConfig, resolveOptimizerConfig } from './utils'
 import { VitestResolver } from './vitestResolver'
 
 interface WorkspaceOptions extends UserWorkspaceConfig {
@@ -26,37 +26,8 @@ export function WorkspaceVitestPlugin(project: WorkspaceProject, options: Worksp
       options() {
         this.meta.watchMode = false
       },
-      // TODO: refactor so we don't have the same code here and in plugins/index.ts
       config(viteConfig) {
-        if (viteConfig.define) {
-          delete viteConfig.define['import.meta.vitest']
-          delete viteConfig.define['process.env']
-        }
-
-        const env: Record<string, any> = {}
-
-        for (const key in viteConfig.define) {
-          const val = viteConfig.define[key]
-          let replacement: any
-          try {
-            replacement = typeof val === 'string' ? JSON.parse(val) : val
-          }
-          catch {
-            // probably means it contains reference to some variable,
-            // like this: "__VAR__": "process.env.VAR"
-            continue
-          }
-          if (key.startsWith('import.meta.env.')) {
-            const envKey = key.slice('import.meta.env.'.length)
-            env[envKey] = replacement
-            delete viteConfig.define[key]
-          }
-          else if (key.startsWith('process.env.')) {
-            const envKey = key.slice('process.env.'.length)
-            env[envKey] = replacement
-            delete viteConfig.define[key]
-          }
-        }
+        const env: Record<string, any> = deleteDefineConfig(viteConfig)
 
         const testConfig = viteConfig.test || {}
 
diff --git a/test/core/test/define.test.ts b/test/core/test/define.test.ts
index 21f8f869606e..6b286a29420e 100644
--- a/test/core/test/define.test.ts
+++ b/test/core/test/define.test.ts
@@ -27,6 +27,11 @@ afterAll(() => {
   process.env.MODE = MODE
 })
 
+test('automatically remove process and global', () => {
+  expect(Object.keys(process).length > 1).toBe(true)
+  expect(Object.keys(global).length > 1).toBe(true)
+})
+
 test('process.env.HELLO_PROCESS is defined on "defined" but exists on process.env', () => {
   expect('HELLO_PROCESS' in process.env).toBe(true)
   expect(process.env.HELLO_PROCESS).toBe('hello process')
diff --git a/test/core/vitest.config.ts b/test/core/vitest.config.ts
index b869e9d40aea..d2252dd7b2dc 100644
--- a/test/core/vitest.config.ts
+++ b/test/core/vitest.config.ts
@@ -19,6 +19,8 @@ export default defineConfig({
     },
   ],
   define: {
+    'process': {},
+    'global': {},
     'import.meta.env.TEST_NAME': '"hello world"',
     'process.env.HELLO_PROCESS': '"hello process"',
     // can reassign