diff --git a/packages/vitest/src/node/plugins/index.ts b/packages/vitest/src/node/plugins/index.ts
index e7eb831a8415..a97e81646841 100644
--- a/packages/vitest/src/node/plugins/index.ts
+++ b/packages/vitest/src/node/plugins/index.ts
@@ -79,6 +79,9 @@ export async function VitestPlugin(options: UserConfig = {}, ctx = new Vitest())
           },
           // disable deps optimization
           cacheDir: undefined,
+          optimizeDeps: {
+            entries: [],
+          },
         }
       },
       async configResolved(viteConfig) {