diff --git a/packages/runtime-core/__tests__/componentPublicInstance.spec.ts b/packages/runtime-core/__tests__/componentPublicInstance.spec.ts
index fe588115d31..2bea4e0eedc 100644
--- a/packages/runtime-core/__tests__/componentPublicInstance.spec.ts
+++ b/packages/runtime-core/__tests__/componentPublicInstance.spec.ts
@@ -257,13 +257,17 @@ describe('component: proxy', () => {
     expect(instanceProxy.isDisplayed).toBe(true)
   })
 
-  test('allow spying on proxy methods', () => {
+ 
+  test('allow jest spying on proxy methods with Object.defineProperty', () => {
+    // #5417
     let instanceProxy: any
     const Comp = {
       render() {},
       setup() {
         return {
-          toggle() {}
+          toggle() {
+            return 'a'
+          }
         }
       },
       mounted() {
@@ -275,13 +279,154 @@ describe('component: proxy', () => {
 
     app.mount(nodeOps.createElement('div'))
 
-    const spy = jest.spyOn(instanceProxy, 'toggle')
+    // access 'toggle' to ensure key is cached
+    const v1 = instanceProxy.toggle()
+    expect(v1).toEqual('a')
+
+    // reconfigure "toggle" to be getter based.
+    let getCalledTimes = 0
+    Object.defineProperty(instanceProxy, 'toggle', {
+      get() {
+        getCalledTimes++
+        return () => 'b'
+      }
+    })
 
+    // getter should not be evaluated on initial definition
+    expect(getCalledTimes).toEqual(0)
+
+    // invoke "toggle" after "defineProperty"
+    const v2 = instanceProxy.toggle()
+    expect(v2).toEqual('b')
+    expect(getCalledTimes).toEqual(1)
+
+    // expect toggle getter not to be cached. it can't be
     instanceProxy.toggle()
+    expect(getCalledTimes).toEqual(2)
 
+    // attaching jest spy, triggers the getter once, cache it and override the property.
+    // also uses Object.defineProperty
+    const spy = jest.spyOn(instanceProxy, 'toggle')
+    expect(getCalledTimes).toEqual(3)
+
+    // expect getter to not evaluate the jest spy caches its value
+    const v3 = instanceProxy.toggle()
+    expect(v3).toEqual('b')
     expect(spy).toHaveBeenCalled()
+    expect(getCalledTimes).toEqual(3)
+  })
+
+  test('defineProperty on proxy property with value descriptor', () => {
+    // #5417
+    let instanceProxy: any
+    const Comp = {
+      render() {},
+      setup() {
+        return {
+          toggle: 'a'
+        }
+      },
+      mounted() {
+        instanceProxy = this
+      }
+    }
+
+    const app = createApp(Comp)
+
+    app.mount(nodeOps.createElement('div'))
+
+    const v1 = instanceProxy.toggle
+    expect(v1).toEqual('a')
+
+    Object.defineProperty(instanceProxy, 'toggle', {
+      value: 'b'
+    })
+    const v2 = instanceProxy.toggle
+    expect(v2).toEqual('b')
+
+    // expect null to be a settable value
+    Object.defineProperty(instanceProxy, 'toggle', {
+      value: null
+    })
+    const v3 = instanceProxy.toggle
+    expect(v3).toBeNull()
+  })
+
+  test('defineProperty on public instance proxy should work with SETUP,DATA,CONTEXT,PROPS', () => {
+    // #5417
+    let instanceProxy: any
+    const Comp = {
+      props: ['fromProp'],
+      data() {
+        return { name: 'data.name' }
+      },
+      computed: {
+        greet() {
+          return 'Hi ' + (this as any).name
+        }
+      },
+      render() {},
+      setup() {
+        return {
+          fromSetup: true
+        }
+      },
+      mounted() {
+        instanceProxy = this
+      }
+    }
+
+    const app = createApp(Comp, {
+      fromProp: true
+    })
+
+    app.mount(nodeOps.createElement('div'))
+    expect(instanceProxy.greet).toEqual('Hi data.name')
+
+    // define property on data
+    Object.defineProperty(instanceProxy, 'name', {
+      get() {
+        return 'getter.name'
+      }
+    })
+
+    // computed is same still cached
+    expect(instanceProxy.greet).toEqual('Hi data.name')
+
+    // trigger computed
+    instanceProxy.name = ''
+
+    // expect "greet" to evaluated and use name from context getter
+    expect(instanceProxy.greet).toEqual('Hi getter.name')
+
+    // defineProperty on computed ( context )
+    Object.defineProperty(instanceProxy, 'greet', {
+      get() {
+        return 'Hi greet.getter.computed'
+      }
+    })
+    expect(instanceProxy.greet).toEqual('Hi greet.getter.computed')
+
+    // defineProperty on setupState
+    expect(instanceProxy.fromSetup).toBe(true)
+    Object.defineProperty(instanceProxy, 'fromSetup', {
+      get() {
+        return false
+      }
+    })
+    expect(instanceProxy.fromSetup).toBe(false)
+
+    // defineProperty on Props
+    expect(instanceProxy.fromProp).toBe(true)
+    Object.defineProperty(instanceProxy, 'fromProp', {
+      get() {
+        return false
+      }
+    })
+    expect(instanceProxy.fromProp).toBe(false)
   })
 
+
   // #864
   test('should not warn declared but absent props', () => {
     const Comp = {
diff --git a/packages/runtime-core/src/componentPublicInstance.ts b/packages/runtime-core/src/componentPublicInstance.ts
index 0413730032c..9bfbfc10371 100644
--- a/packages/runtime-core/src/componentPublicInstance.ts
+++ b/packages/runtime-core/src/componentPublicInstance.ts
@@ -455,8 +455,9 @@ export const PublicInstanceProxyHandlers: ProxyHandler<any> = {
     descriptor: PropertyDescriptor
   ) {
     if (descriptor.get != null) {
-      this.set!(target, key, descriptor.get(), null)
-    } else if (descriptor.value != null) {
+      // invalidate key cache of a getter based property #5417
+      target.$.accessCache[key] = 0;
+    } else if (hasOwn(descriptor,'value')) {
       this.set!(target, key, descriptor.value, null)
     }
     return Reflect.defineProperty(target, key, descriptor)