diff --git a/lib/rules/define-macros-order.js b/lib/rules/define-macros-order.js
index 9c8ea45e6..1db259fa1 100644
--- a/lib/rules/define-macros-order.js
+++ b/lib/rules/define-macros-order.js
@@ -19,6 +19,17 @@ const MACROS_PROPS = 'defineProps'
 const ORDER = [MACROS_EMITS, MACROS_PROPS]
 const DEFAULT_ORDER = [MACROS_PROPS, MACROS_EMITS]
 
+/**
+ * @param {VElement} scriptSetup
+ * @param {ASTNode} node
+ */
+function inScriptSetup(scriptSetup, node) {
+  return (
+    scriptSetup.range[0] <= node.range[0] &&
+    node.range[1] <= scriptSetup.range[1]
+  )
+}
+
 /**
  * @param {ASTNode} node
  */
@@ -33,9 +44,10 @@ function isUseStrictStatement(node) {
 /**
  * Get an index of the first statement after imports and interfaces in order
  * to place defineEmits and defineProps before this statement
+ * @param {VElement} scriptSetup
  * @param {Program} program
  */
-function getTargetStatementPosition(program) {
+function getTargetStatementPosition(scriptSetup, program) {
   const skipStatements = new Set([
     'ImportDeclaration',
     'TSInterfaceDeclaration',
@@ -45,7 +57,11 @@ function getTargetStatementPosition(program) {
   ])
 
   for (const [index, item] of program.body.entries()) {
-    if (!skipStatements.has(item.type) && !isUseStrictStatement(item)) {
+    if (
+      inScriptSetup(scriptSetup, item) &&
+      !skipStatements.has(item.type) &&
+      !isUseStrictStatement(item)
+    ) {
       return index
     }
   }
@@ -104,7 +120,10 @@ function create(context) {
       'Program:exit'(program) {
         const shouldFirstNode = macrosNodes.get(order[0])
         const shouldSecondNode = macrosNodes.get(order[1])
-        const firstStatementIndex = getTargetStatementPosition(program)
+        const firstStatementIndex = getTargetStatementPosition(
+          scriptSetup,
+          program
+        )
         const firstStatement = program.body[firstStatementIndex]
 
         // have both defineEmits and defineProps
diff --git a/tests/lib/rules/define-macros-order.js b/tests/lib/rules/define-macros-order.js
index ce5f30040..65a07887f 100644
--- a/tests/lib/rules/define-macros-order.js
+++ b/tests/lib/rules/define-macros-order.js
@@ -387,6 +387,42 @@ tester.run('define-macros-order', rule, {
           line: 3
         }
       ]
+    },
+    {
+      filename: 'test.vue',
+      code: `
+        <script>
+          import 'test2'
+          export default { inheritAttrs: false };
+        </script>
+
+        <script setup>
+          import 'test'
+
+          defineEmits(['update:test'])
+          const props = defineProps({ test: Boolean });
+        </script>
+      `,
+      output: `
+        <script>
+          import 'test2'
+          export default { inheritAttrs: false };
+        </script>
+
+        <script setup>
+          import 'test'
+
+          const props = defineProps({ test: Boolean });
+
+          defineEmits(['update:test'])
+        </script>
+      `,
+      errors: [
+        {
+          message: message('defineProps'),
+          line: 11
+        }
+      ]
     }
   ]
 })